Investigation of the relationship between NFKB1 polymorphisms and telomere length and apoptosis in patients with type-2 diabetes

Purpose: Type 2 diabetes mellitus (T2DM) is a heterogeneous, chronic, and metabolic disease that affects significant proportion of the global population. This study aimed to evaluate effect NFKB1 -94 ATTG ins/del polymorphisms on expression apoptosis genes telomere length (TL) in patients with T2DM compared healthy individuals.
 Materials Methods: Sixty-nine sixty people were enrolled study. DNA RNA isolated from blood samples. genotypes identified by Sanger sequencing. For TL analyses investigate caspase-3, caspase-9, bax, bcl2 genes, RT-PCR was utilized.
 Results: There difference between genotype control group (OR:0.4792 (0.2345-1.011)). However, distribution other genotype/alleles (ins/ins del/del) showed no groups. The allelic frequency 0.455/0.235 for 0.435/0.165 group. An increase mRNA caspase-9 Bax observed group, while decrease Bcl2 gene found shorter than individuals. 
 Conclusion: show differences patients. We activated shortened T2DM. relationship could not be determined.